Desire can be the source of great Dukkha whether fulfilled or not. Some desires, however are wholesome and these should be pursued, but even these can be a source of Dukkha. Working with desires is an important part of practice. Doug and Jon discuss their different approaches.
Books mentioned:
Anālayo, Compassion and Emptiness
Gua Gu , Silent Illumination
Recommended on the topic of desire: Mark Epstein-- Open to Desire